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Dr. David Speert

David SpeertCUPIC Director

Sauder Family Professor and Head, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia

Dr. David Speert has been Head of the Division of Infectious and Immunological Diseases since 1991. His research interests include the pathogenetic role of bacteria in cystic fibrosis, the epidemiology of Pseudomonas aeruginosa and Burkholderia cepacia complex in CF and innate defenses against infection in children. He is also heading a birth cohort study in the Western Cape Province of South Africa to investigate the mechanisms of enhanced morbidity and mortaility in children born to, but not infected by, HIV-infected mothers.

Research in Dr. Speert's laboratory is directed at gaining a clearer understanding of how infections of the lung are acquired by patients with cystic fybrosis. He is exploring phagocytic cell defence of the lungs as well as bacterial determinants which permit Pseudomonas aeruginosa and Burkholderia cepacia complex to subvert normal host defences and establish infection. Work in his laboratory is also directed at gaining a better understanding of the role of innate immunity in regulating inflammation in health and disease, both infectious and auto-inflammatory. 

Work in Dr. Speert's lab has been supported by grants from the Canadian Cystic Fibrosis Foundation, the Canadian Institutes for Health Research, the Canadian Bacterial Diseases Network, the BC Lung Association, the BC Children's Hospital Foundation and Genome Canada.


Laboratory Members

Selected Publications