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Dr. Tobias Kollmann


Clinician Scientist, CFRI
Assistant Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia

We are systematically analyzing the human neonatal and infant response to danger signals (e.g. TLR-ligands) and vaccines. This way we will learn what aspects of the newborn's immune system work well. With that knowledge, we hope to identify immune modulators or vaccine adjuvants that would help protect newborns from disease, and aid in their immune response to vaccines. This work is done in close collaboration with several larger national and international research centers through large clinical trials. Our lab uses state-of-the-art technology to get the most information out of the smallest samples. We also are developing the necessary bioinformatics tools to enable optimal analysis and mining of this complex set of information.

Parallel to the human descriptive studies, we are developing a vaccine platform in animals, where we can test our vaccines and define the exact molecular mechanisms at work. For example, we use genetically altered strains of Listeria monocytogenes to target our vaccines to only those cells we want to infect, to then deliver its vaccine antigen, induce the desired immune response, and disappear - all without causing any harm to the newborn. Our preliminary data gives us great hope that our final goal is within reach.



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Selected Publications